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MagQu Bio-Functionalised Magnetic Beads


MagQu Bio Reagents

Bio-Functionalised Magnetic Beads

With the use of these bio magnetic beads, MagQu offers an advanced assay platform, called Immuno-Magnetic Reduction (IMR) bio-assays. Compared to the sandwich-type and plan-type labeling, this assay is wash free, less time consuming, customisable, highly specific and highly sensitive.

The reagent is a solution of homogeneously dispersed magnetic nanoparticles, which are coated with hydrophilic surfactants and bio-probes such as antibodies. These magnetic nanoparticles will oscillate with AC magnetic fields via magnetic interaction, when the external multiple AC magnetic fields are applied.

Via the bio-probes on the outmost shell, magnetic nanoparticles associate with bio-molecules, magnetically labelling them. Along with the association, the magnetic nanoparticles become either larger or clustered, and less responsive to the external multiple AC magnetic fields. Since their magnetic susceptibility Χac is therefore reduced, the target bio molecules can be detected.




Bio-Functionalised Magnetic Beads


Dextran coated Magnetic Beads

I. Dextran coated Fe3O4 magnetic beads

consisting of single-crystal Fe3O4 coated with dextran dispersed in PBS solution. Sizes ranging from 20 to 160 nm in hydrodynamic diameter.


Streptavidin-dextran coated Fe3O4 magnetic beads

II. Streptavidin-dextran coated Fe3O4 magnetic beads

providing sites for antibodies to sit on.
To obtain the antibody-coated Fe3O4 magnetic beads: First mix the type II beads with biotinyl-antibodies, and then remove unbound biotinyl-antibodies with magnetic separation.

Antibody coated Fe3O4 magnetic beads

III. Antibody coated Fe3O4 magnetic beads

customisable for versatile biomedical applications such as immunoassay, cell sorting, protein purification, MRI contrast enhancement etc. Particle sizes ranging from 20 to 160 nm in diameter.

Amino group coated Fe3O4 magnetic beads

IV. Amino group coated Fe3O4 magnetic beads

functionalised with amino group NH3+, electrically positive and easily bound with electrically negative-charged molecules.
Useful for magnetic labeling of nucleic acids, for applications such as nucleic-acid purification and magnetofection.


Why IMR?

Compared to ELISA, HPLC and LC/MS/MS, IMR features

  • Very Easy Operation, wash step unnecessary, sample prepurification unecessary, sample colour independent

  • High Mobility

  • High Sensitivity: 10 ppt ~ 10-4 ppt

  • Low Budget

In terms of applications, IMR features

  • Direct, Homogeneous and On-site assays that ELISA does not offer.

  • Direct and On-site assays that LC/MS/MS does not offer.


Specifications upon Reuqest.

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